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Senior Scientist

Company: Zoetis
Location: Fort Collins
Posted on: May 3, 2021

Job Description:

Zoetis is seeking a talented and experienced protein engineer to contribute to our efforts in Global Therapeutics Research at Zoetis. This individual will partner with project teams to build a basic understanding of disease targets, pathways, and therapeutic mechanisms of action through structure-based protein design, engineering, and computational modeling.

The successful candidate should have knowledge of antibodies and/or protein interactions and relevant experience with high resolution structure determination methods such as Cryo EM, in silico protein homology models, protein docking, and epitope mapping. Experience with and understanding of peptide design, protein design and engineering, molecular biology, and protein characterization is preferred. Excellent communication, organizational and interpersonal skills are essential. Some travel required.

Please note: This position is for a fixed term of 3.5 years.

POSITION RESPONSIBILITIES:

  • Protein and antibody in silico design and structural mapping
  • Epitope mapping and immunogen design
  • Develop understanding of protein-protein interactions and target inhibition
  • Antibody optimization and affinity maturation using rational design techniques
  • Collaborate across multiple scientific disciplines to understand mechanistic biology
  • Work closely with team leads to identify potential therapeutic substrate
  • Directly communicate with external partners for collaborations and outsourcing.

EDUCATION AND EXPERIENCE:

  • Educational background: Ph.D. in engineering, structural biology, computational biology, molecular or cellular biology, immunology, biochemistry, or related field; or M.S. with at least 5 years relevant experience.
  • Training or experience in biological sciences focusing on protein engineering and protein modeling with an emphasis on understanding epitopes and protein-protein interactions.
  • Expertise in single particle cryo-EM processes (including sample/grid preparation and screening, data collection and processing, three-dimensional reconstruction and model building).
  • Expertise in protein modeling techniques including homology modeling, epitope/paratope mapping, in silico protein optimization, and immunogen design.
  • Exposure to affinity maturation & antibody optimization approaches (phage, yeast, mammalian, or mRNA display; rational design techniques) preferred.
  • Some experience with molecular biology and molecular cloning techniques including subcloning, site-directed mutagenesis, PCR and DNA manipulation is desired.
  • Exposure to protein expression & isolation (mammalian & bacterial systems), affinity chromatography, protein biochemistry and protein quantification (SDS-PAGE protein gels, Westerns, analytical SEC, ELISAs, SPR) is a plus.
  • Familiarity with Linux OS (install, configure and maintain) is a strong plus.
  • Self-starter, able to prioritize work and work efficiently, design experiments with minimal supervision, and able work across teams remotely and face-to-face.
  • Experience interacting with CROs or external partnerships
  • Excellent verbal/written communication, organizational and interpersonal skills
  • Computer skills required: Microsoft Word, Excel, Outlook, BLAST, Vector NTI or equivalent, protein modeling software (MOE, Rosetta, etc.)

ADDITIONAL INFORMATION:

Work environment:

The placement of this position will be primarily in Boulder, CO, with laboratories located in Fort Collins, CO. This person will be expected to travel to Fort Collins, CO on a regular basis to interact with project teams. Occasional travel to R&D headquarters in Kalamazoo, MI may also be requested.

The person filling this position may work partly in a laboratory setting. There may be exposure to animal pathogens and chemicals. There may be handling of, and/or exposure to animal tissue and zoonotic organisms

Zoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact.

Full timeFixed Term/Temporary (Fixed Term)ColleagueZoetis is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status or any other protected classification. Disabled individuals are given an equal opportunity to use our online application system. We offer reasonable accommodations as an alternative if requested by an individual with a disability. Please contact Zoetis Colleague Services at zoetiscolleagueservices@zoetis.com to request an accommodation. Zoetis also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as employment eligibility verification requirements of the Immigration and Nationality Act. All applicants must possess or obtain authorization to work in the US for Zoetis. Zoetis retains sole and exclusive discretion to pursue sponsorship for the acquisition or maintenance of nonimmigrant status and employment eligibility, considering factors such as availability of qualified US workers. Individuals requiring sponsorship must disclose this fact. Please note that Zoetis seeks information related to job applications from candidates for jobs in the U.S. solely via the following: (1) our company website at www.Zoetis.com/careers site, or (2) via email to/from addresses using only the Zoetis domain of @zoetis.com. In addition, Zoetis does not use Google Hangout for any recruitment related activities. Any solicitation or request for information related to job applications with Zoetis via any other means and/or utilizing email addresses with any other domain should be disregarded. In addition, Zoetis will never ask candidates to make any type of personal financial investment related to gaining employment with Zoetis.

Keywords: Zoetis, Fort Collins , Senior Scientist, Other , Fort Collins, Colorado

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